Overview of projects

The projects have one common theme: T cell recognition of peptide fragments derived from antibody molecules. Such fragments are generated by antigen processing of antibody molecules in antigen presenting cells (APC). The fragments are presented by MHC class II molecules on antigen presenting cells to T cells.

The concept of antibody molecules as antigens for T cells has been pioneered by us and is by now generally accepted. It is a topic of importance for the following reasons:

1) Immune regulation and autoimmunity

2) Tumor immunology. B cell lymphomas and multiple myelomas

3) Vaccines. Vaccibodies & Troy bodies

Group Members

• Bjarne Bogen
• Keith Thompson
• Alexandre Corthay
• Ludvig A Munthe
• Katrin Lundin
• Karoline W. Schjetne
• Gro Tunheim
• Audun Os
• Agnete Brunsvik
• Peter O. Hofgaard
• Hilde Omholt
• Pier Rufini
• Michael Zangani
• Johanne Jacobsen
  
• Marianne Frøyland
• Miriam Zangani
  
• Jon Magnus Haga
• Tom Ole Løvik
  
• Egil Røsjø