1)Immune regulation and autoimmunity
2) Tumor immunology. B cell lymphomas and multiple myelomas
3) Vaccines. Troy bodies & Vaccibodies
Antibodies have several major advantages as molecules used for manipulation of the immune system. First, they are stable molecules in vivo with long half-lives. Second, their V regions endow them with binding specificity. Third, much is known about genetic engineering of antibody molecules. Thus T cell epitopes may be inserted in the constant domains of antibodies, and V regions of desired specificity, e.g. for cell surface molecules, may be added. Such engineered antibody molecules function as Trojan horses, in the sense that they illicitly enter cells and release their content by antigen processing. We have therefore coined them Troy-bodies, and plan to use them for vaccination purposes or for induction of T cell tolerance.
Group Members
- Bjarne Bogen
- Keith Thompson
- Alexandre Corthay
- Ludvig A Munthe
- Katrin Lundin
- Karoline W. Schjetne
- Gro Tunheim
- Audun Os
- Agnete Brunsvik
- Peter O. Hofgaard
- Hilde Omholt
- Pier Rufini
- Michael Zangani
- Johanne Jacobsen
- Marianne Frøyland
- Miriam Zangani
- Jon Magnus Haga
- Tom Ole Løvik
- Egil Røsjø
